Curcumin Inhibits Constitutive STAT3 Phosphorylation in Human Pancreatic Cancer Cell lines and Downregulation of Survivin/BIRC5 Gene Expression

被引：111

作者：

Glienke, W. ^{[1
]}

Maute, L. ^{[1
]}

Wicht, J. ^{[1
]}

Bergmann, L. ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 2, Univ Hosp, D-60590 Frankfurt, Germany

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 02期

关键词：

Pancreatic cancer; Curcumin; Survivin/BIRC5; Apoptosis; STAT3; MOLECULAR TARGETS; SIGNAL TRANSDUCER; SUPPRESSES GROWTH; APOPTOSIS; ACTIVATION; EPIDEMIOLOGY;

D O I：

10.3109/07357900903287006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The purpose of this study was to determine the effect of curcumin on Survivin/BIRC5 and on the role of signal transducer and activator of transcription 3 (STAT3) activation in Survivin/BIRC5. We incubated two pancreatic cancer cell lines with different amounts of curcumin. This resulted in a downregulation of proliferation in all cell lines tested. The expression of Survivin/BIRC5 on mRNA and protein level was significantly downregulated and the phosphorylation of STAT3 was blocked. Treatment of pancreatic cancer cells with curcumin resulted in an induction of apoptosis. The results indicate that curcumin inhibits several key factors in cancer cellular pathways and may be of interest in pancreatic cancer.

引用

收藏

页码：166 / 171

页数：6

相关论文

共 28 条

[1]

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl [J].

Anto, RJ ;

Mukhopadhyay, A ;

Denning, K ;

Aggarwal, BB .

CARCINOGENESIS, 2002, 23 (01) :143-150

[2]

Buettner R, 2002, CLIN CANCER RES, V8, P945

[3]

WP1066 disrupts janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells [J].

Ferrajoli, Alessandra ;

Faderl, Stefan ;

Van, Quin ;

Koch, Patricia ;

Harris, David ;

Liu, Zhiming ;

Hazan-Halevy, Inbal ;

Wang, Yongtao ;

Kantarjian, Hagop M. ;

Priebe, Waldemar ;

Estrov, Zeev .

CANCER RESEARCH, 2007, 67 (23) :11291-11299

[4]

STAT3 as a central mediator of neoplastic cellular transformation [J].

Frank, David A. .

CANCER LETTERS, 2007, 251 (02) :199-210

[5]

Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells [J].

Glienke, Wolfgang ;

Maute, Luise ;

Wicht, Johannes ;

Bergmann, Lothar .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (05) :874-880

[6]

Persistent activation of Stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells [J].

Gritsko, T ;

Williams, A ;

Turkson, J ;

Kaneko, S ;

Bowman, T ;

Huang, M ;

Nam, S ;

Eweis, I ;

Diaz, N ;

Sullivan, D ;

Yoder, S ;

Enkemann, S ;

Eschrich, S ;

Lee, JH ;

Beam, CA ;

Cheng, J ;

Minton, S ;

Muro-Cacho, CA ;

Jove, R .

CLINICAL CANCER RESEARCH, 2006, 12 (01) :11-19

[7]

Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, C-myc, Bcl-XL, NF-κB, and p53 [J].

Han, SS ;

Chung, ST ;

Robertson, DA ;

Ranjan, D ;

Bondada, S .

CLINICAL IMMUNOLOGY, 1999, 93 (02) :152-161

[8]

Evaluation of potential Stat3-regulated genes in human breast cancer [J].

Hsieh, FC ;

Cheng, G ;

Lin, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 335 (02) :292-299

[9]

Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells [J].

Kami, K ;

Doi, R ;

Koizumi, M ;

Toyoda, E ;

Mori, T ;

Ito, D ;

Kawaguchi, Y ;

Fujimoto, K ;

Wada, M ;

Miyatake, SI ;

Imamura, M .

SURGERY, 2005, 138 (02) :299-305

[10]

KORUTLA L, 1994, BIOCHIM BIOPHYS ACTA, V3, P597