Glutathione S-transferase polymorphisms and risk of ovarian cancer:: A HuGE review

被引：44

作者：

Coughlin, SS ^{[1
]}

Hall, IJ ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Epidemiol & Hlth Serv Res Branch, Div Canc Prevent & Control, Atlanta, GA 30341 USA

来源：

GENETICS IN MEDICINE | 2002年 / 4卷 / 04期

关键词：

epidemiology; glutathione S-transferases; GSTM1; GSTP1; GSTT1; ovarian cancer;

D O I：

10.1097/00125817-200207000-00003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Glutathione S-transferases (GSTs) catalyze the conjugation of glutathione to numerous potentially genotoxic compounds. The GSTM1 gene codes for the enzyme glutathione S-transferase-mu, the GSTT1 gene codes for the enzyme glutathione S-transferase-theta, and the GSTP1 gene codes for the enzyme glutathione S-transferase-pi. GSTM1 is polymorphically expressed, and three alleles have been identified (GSTM1-0, GSTM1a, and GSTM1b). Two functionally different genotypes at the GSTT1 locus have been described. Individuals with homozygous deletions of GSTM or GSTT have reduced or no glutathione S-transferase activity and therefore may be unable to eliminate electrophilic carcinogens as efficiently. However, results of epidemiologic studies do not confirm associations between GSTM1, GSTT1, and GSTP1 and epithelial ovarian cancer.

引用

页码：250 / 257

页数：8

共 57 条

[1]

Abou Ghalia A, 2000, ANTICANCER RES, V20, P1229

[2]

AliOsman F, 1997, J BIOL CHEM, V272, P10004

[3]

*AM CANC SOC INC, 2002, CANC FACTS FIG

[4]

[Anonymous], 1996, NIH PUB

[5]

GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer [J].

Baxter, SW ;

Thomas, EJ ;

Campbell, IG .

CARCINOGENESIS, 2001, 22 (01) :63-65

[6]

Characterization and chromosome location of the gene GSTZ1 encoding the human Zeta class glutathione transferase and maleylacetoacetate isomerase [J].

Blackburn, AC ;

Woollatt, E ;

Sutherland, GR ;

Board, PG .

CYTOGENETICS AND CELL GENETICS, 1998, 83 (1-2) :109-114

[7]

Board PG, 1997, BIOCHEM J, V328, P929

[8]

Identification, characterization, and crystal structure of the omega class glutathione transferases [J].

Board, PG ;

Coggan, M ;

Chelvanayagam, G ;

Easteal, S ;

Jermiin, LS ;

Schulte, GK ;

Danley, DE ;

Hoth, LR ;

Griffor, MC ;

Kamath, AV ;

Rosner, MH ;

Chrunyk, BA ;

Perregaux, DE ;

Gabel, CA ;

Geoghegan, KF ;

Pandit, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) :24798-24806

[9]

Butkiewicz D, 2000, ENVIRON MOL MUTAGEN, V35, P99, DOI 10.1002/(SICI)1098-2280(2000)35:2<99::AID-EM4>3.3.CO

[10]

2-U

← 1 2 3 4 5 6 →