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Adipobiology of disease: Adipokines and adipokine-targeted pharmacology

被引：129
作者：
Chaldakov, GN [1 ]
Stankulov, IS
Hristova, M
Ghenev, PI
机构：
[1] Med Univ, Dept Forens Med, Div Cell Biol, BG-9002 Varna, Bulgaria
[2] Med Univ, Endocrinol Clin, BG-9002 Varna, Bulgaria
[3] Med Univ, Dept Gen & Clin Pathol, BG-9002 Varna, Bulgaria
来源：
CURRENT PHARMACEUTICAL DESIGN | 2003年 / 9卷 / 12期
关键词：
D O I：
10.2174/1381612033455152
中图分类号：
R9 [药学];
学科分类号：
1007 [药学];
摘要：
In recent years, the simple paradigm of adipose tissue as merely a fat store is rapidly evolving into a complex paradigm of this tissue as multipotential secretory organ, partitioned into a few large depots, including visceral and subcutaneous location, and many small depots, A associated with a variety of organs in the human body. The major secretory compartment of adipose tissue consists of adipocytes, fibroblasts, and mast cells. These cells, using endocrine, paracrine and autocrine pathways, secrete multiple bioactive molecules, conceptualized as adipokines or adipocytokines. This review examines current information in adipobiology of various diseases besides obesity and related diseases Such as type 2 diabetes, metabolic syndrome, and cardiovascular disease. Finally, we emphasize the possibilities for adipokine-targeted pharmacology in adiponectin (Acrp30, apM1, AdipoQ, GBP28), angiotensin II, estrogens, nerve growth factor, tumor necrosis factor-alpha, and also adipose mast cells.
引用
收藏
页码：1023 / 1031
页数：9
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