Epidermal deletion of Rac1 causes stem cell depletion, irrespective of whether deletion occurs during embryogenesis or adulthood

被引：13

作者：

Benitah, Salvador A. ^{[1
]}

Watt, Fiona M. ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, Keratinocyte Lab, London, England

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2007年 / 127卷 / 06期

关键词：

D O I：

10.1038/sj.jid.5700738

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

引用

页码：1555 / 1557

页数：3

共 11 条

[1] Stem cell depletion through epidermal deletion of Rac1 [J].

Benitah, SA ;

Frye, M ;

Glogauer, M ;

Watt, FM .

SCIENCE, 2005, 309 (5736) :933-935

[2] Formation of a functional thymus initiated by a postnatal epithelial progenitor cell [J].

Bleul, Conrad C. ;

Corbeaux, Tatiana ;

Reuter, Alexander ;

Fisch, Paul ;

Moenting, Juergen Schulte ;

Boehm, Thomas .

NATURE, 2006, 441 (7096) :992-996

[3] Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis [J].

Braun, KM ;

Niemann, C ;

Jensen, UB ;

Sundberg, JP ;

Silva-Vargas, V ;

Watt, FM .

DEVELOPMENT, 2003, 130 (21) :5241-5255

[4]

BYRNE C, 1994, DEVELOPMENT, V120, P2369

[5] Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis [J].

Chrostek, Anna ;

Wu, Xunwei ;

Quondamatteo, Fabio ;

Hu, Rong ;

Sanecka, Anna ;

Niemann, Catherin ;

Langbein, Lutz ;

Haase, Ingo ;

Brakebusch, Cord .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (18) :6957-6970

[6] Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment [J].

Frye, M ;

Gardner, C ;

Li, ER ;

Arnold, I ;

Watt, FM .

DEVELOPMENT, 2003, 130 (12) :2793-2808

[7] Different consequences of β1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication [J].

López-Rovira, T ;

Silva-Vargas, V ;

Watt, FM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (06) :1215-1227

[8]

RAMIREZ A, 1994, DIFFERENTIATION, V58, P53, DOI 10.1007/s002580050065

[9] A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor [J].

Sibilia, M ;

Steinbach, JP ;

Stingl, L ;

Aguzzi, A ;

Wagner, EF .

EMBO JOURNAL, 1998, 17 (03) :719-731

[10] β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells [J].

Silva-Vargas, V ;

Lo Celso, C ;

Giangreco, A ;

Ofstad, T ;

Prowse, DM ;

Braun, KM ;

Watt, FM .

DEVELOPMENTAL CELL, 2005, 9 (01) :121-131

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