Somatic hypermutation (SHM) introduces nucleotide substitutions into immunoglobulin variable (Ig V) region genes at all four bases, but the mutations at C/G and A/T pairs are achieved by distinct mechanisms. Mutations at C/G pairs are a direct consequence of the C -> U deamination catalyzed by activation-induced deaminase ( AID). Mutations at A/T pairs, however, require a second mutagenic process that occurs during patch repair of the AID-generated U/G mismatch. Several DNA polymerases have been proposed to play a role in SHM, but accumulating evidence indicates that the mutations at A/T are overwhelmingly achieved by recruitment of DNA polymerase eta.
机构:
Imperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, EnglandImperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, England
Barnes, DE
;
Lindahl, T
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Imperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, EnglandImperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, England
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Delbos, F
;
De Smet, A
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Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
De Smet, A
;
Faili, A
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Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Faili, A
;
Aoufouchi, S
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Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Aoufouchi, S
;
Weill, JC
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Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Weill, JC
;
Reynaud, CA
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Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
机构:
Imperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, EnglandImperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, England
Barnes, DE
;
Lindahl, T
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h-index: 0
机构:
Imperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, EnglandImperial Canc Res Fund, Clare Hall Labs, London Res Inst, S Mimms EN6 3LD, Herts, England
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Delbos, F
;
De Smet, A
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h-index: 0
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
De Smet, A
;
Faili, A
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h-index: 0
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Faili, A
;
Aoufouchi, S
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h-index: 0
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Aoufouchi, S
;
Weill, JC
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h-index: 0
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France
Weill, JC
;
Reynaud, CA
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h-index: 0
机构:
Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, FranceUniv Paris 05, Fac Med Necker Enfants Malad, INSERM, U373, F-75730 Paris, France