Tip-enhanced Raman spectra of picomole quantities of DNA nucleobases at Au(111)

被引：117

作者：

Domke, Katrin F. ^{[1
]}

Zhang, Dai ^{[1
]}

Pettinger, Bruno ^{[1
]}

机构：

[1] Max Planck Soc, Fritz Haber Inst, Dept Phys Chem, D-14195 Berlin, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 21期

关键词：

D O I：

10.1021/ja071107q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show that label-free detection of picomole amounts of the four nucleobases, respectively, adsorbed at atomically smooth Au(111) is straightforward with tip-enhanced Raman (TER) spectroscopy. In addition to TER spectra that allow identification of the corresponding DNA base, topographic images of the nanometer-sized sample can be obtained. Only 130 adenine molecules present in the enhanced field region in the tip-sample gap are sufficient to record the adenine fingerprint, that is, the Raman band of the characteristic ring-breathing mode at 734 cm(-1).

引用

页码：6708 / +

页数：3

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