Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors

被引：120

作者：

Advani, SJ

Sibley, GS

Song, PY

Hallahan, DE

Kataoka, Y

Roizman, B

Weichselbaum, RR

机构：

[1] Univ Chicago Hosp, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA

[2] Univ Chicago, Marjorie B Kovler Viral Oncol Labs, Chicago, IL 60637 USA

来源：

GENE THERAPY | 1998年 / 5卷 / 02期

关键词：

malignant gliomas; mouse models; attenuated herpes viruses;

D O I：

10.1038/sj.gt.3300546

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Human U-87 malignant glioma xenografts in mice were exposed to ionizing radiation, inoculated with a herpes simplex virus 1 mutant R3616 lacking both copies of the gamma(1)34.5 gene, ore received both virus and radiation. Dual treatment caused a significantly greater reduction in volume or total regression of tumors than either radiation or infection alone. The significantly enhanced oncolytic effects of the combined treatment correlate with two- to five-fold enhanced replication in irradiated tumor cells than in tumors receiving virus only. In addition, in situ hybridization with viral DNA probes showed that infected tumor cells were the dominant landscape of irradiated tumors and much less apparent in the nonirradiated tumors administered this virus.

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页码：160 / 165

页数：6

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