Antimicrobial activity of novel furanonaphthoquinone analogs

被引：33

作者：

Nagata, K

Hirai, KI

Koyama, J

Wada, Y

Tamura, T

机构：

[1] Hyogo Coll Med, Dept Bacteriol, Nishinomiya, Hyogo 663, Japan

[2] Hyogo Coll Med, Clin Lab, Nishinomiya, Hyogo 663, Japan

[3] Kanazawa Med Univ, Dept Anat, Uchinada, Ishikawa 92002, Japan

[4] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 658, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 03期

关键词：

D O I：

10.1128/AAC.42.3.700

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 mu g/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 mu g/ml. Fungi, including pathogenic species, were sensitive to FNQ with MICs similar to those of amphotericin B.

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收藏

页码：700 / 702

页数：3

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