Quantum chemical studies of radical-containing enzymes

This review attempts to cover most of what has been done using accurate quantum chemical methods on mechanisms of radical enzymes. The radical enzymes reviewed are those in which amino acid or cofactor radicals have been found. A pattern clearly evident is that finding the right enzyme mechanism will generally require several years of gradually refined computational modeling. Typical examples are photosystem II, cytochrome c oxidase, and ribonucleotide reductase, where model calculations have appeared stretching over the entire 5-year period from the first study until now.