Ca2+ signaling in dendritic spines

被引：108

作者：

Bloodgood, Brenda L. ^{[1
]}

Sabatini, Bernardo L. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2007年 / 17卷 / 03期

关键词：

LONG-TERM DEPRESSION; NR2B-CONTAINING NMDA RECEPTORS; BACKPROPAGATING ACTION-POTENTIALS; TIMING-DEPENDENT PLASTICITY; CA1 PYRAMIDAL NEURONS; SYNAPTIC PLASTICITY; CALCIUM-CHANNELS; HIPPOCAMPAL-NEURONS; SINGLE SPINES; COINCIDENCE DETECTION;

D O I：

10.1016/j.conb.2007.04.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have revealed that Ca2+ signals evoked by action potentials or by synaptic activity within individual dendritic spines are regulated at multiple levels. Ca2+ influx through glutamate receptors and voltage-sensitive Ca2+ channels located on spines depends on the channel subunit composition, the activity of kinases and phosphatases, the local membrane potential and past patterns of activity. Furthermore, sources of spine Ca2+ interact nonlinearly such that activation of one Ca2+ channel can enhance or depress the activity of others. These studies have revealed that each spine is a complex and partitioned Ca2+ signaling domain capable of autonomously regulating the electrical and biochemical consequences of synaptic activity.

引用

页码：345 / 351

页数：7

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