Recent developments in the use of vitamin D analogues

The non-classical effects of 1 alpha,25-dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3) create possible therapeutic applications for immune modulation (e.g., autoimmune diseases and graft rejection), inhibition of cell proliferation (e.g., psoriasis, cancer) and induction of cell differentiation (e.g., cancer). The major drawback related to the use of 1 alpha,25(OH)(2)D-3 is its calcaemic effect, which prevents the application of pharmacological concentrations. Intensive research has led to the development of analogues of 1 alpha,25(OH)(2)D-3 characterised by a clear dissociation-of the antiproliferative and prodifferentiating capacity from the calcaemic effects. Due to this dissociation, these analogues can be used not only for the treatment of bone disorders but also for non-classical applications. In the present review, a summary is given on the use of the 1 alpha,25(OH)(2)D-3 analogues for the treatment of cancer, skin and immune disorders and for the prevention of graft rejection. Moreover a brief overview is given on the use of analogues for secondary hyperparathyroidism.