High rate of constitutional chromosomal rearrangements in apparently sporadic ALS

被引：16

作者：

Meyer, T

Alber, B

Roemer, K

Martin, T

Kalscheuer, VM

Göttert, E

Zang, KD

Ludolph, AC

Ropers, HH

Prudlo, J

机构：

[1] Humboldt Univ, Charite Univ Hosp, Dept Neurol, Berlin, Germany

[2] Univ Ulm, Dept Neurol, D-89069 Ulm, Germany

[3] Univ Hosp, Dept Virol, Homburg, Germany

[4] Univ Hosp, Dept Human Genet, Homburg, Germany

[5] Univ Hosp, Dept Neurol, Homburg, Germany

[6] Max Planck Inst Mol Genet, Berlin, Germany

来源：

NEUROLOGY | 2003年 / 60卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000055088.52681.F1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Of 85 patients with ALS, the authors identified 3 patients with balanced translocations and 2 patients with pericentric inversions, all affecting distinct chromosomal loci. The high rate of constitutional aberrations (5.9%) suggests that ALS is, in part, associated with recombination-based rearrangements of genomic sequences.

引用

页码：1348 / 1350

页数：3

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