Expression of IP-10 related to angiogenesis in uterine cervical cancers

被引:41
作者
Sato, E. [1 ]
Fujimoto, J. [1 ]
Toyoki, H. [1 ]
Sakaguchi, H. [1 ]
Alam, S. M. [1 ]
Jahan, I. [1 ]
Tamaya, T. [1 ]
机构
[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5011194, Japan
关键词
IP-10; VEGF; angiogenesis; angiogenic inhibitor; uterine cervical cancer;
D O I
10.1038/sj.bjc.6603790
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Angiogenesis is essential for development, growth and advancement of solid tumours. Interferon-gamma-inducible protein 10 (IP-10) regulates lymphocyte chemotaxis, mediates vascular pericyte proliferation and acts as an angiostatic agent, thus inhibiting tumour growth. This prompted us to study the clinical implications of IP-10 expression related to angiogenesis in uterine cervical cancers. The levels of IP-10 decreased with advancement, and the prognosis of the 30 patients with low IP-10 expression in uterine cervical cancers was poor (66%), whereas the 24-month survival rate of the other patients with high IP-10 expression was 90%. Furthermore, IP-10 levels significantly reverse-correlated with vascular endothelial growth factor (VEGF) levels in uterine cervical cancers. Interferon-gamma-inducible protein 10 might work on suppression of angiogenesis associated with VEGF in advancement, and can be recognised as a prognostic indicator. Furthermore, IP-10 activation might be effective on the suppression of regrowth or recurrence after intensive treatment for advanced cervical cancers.
引用
收藏
页码:1735 / 1739
页数:5
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