Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens

被引：69

作者：

Wikstrom, Matthew E.

Stumbles, Philip A.

机构：

[1] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Div Cell Biol, Perth, WA 6872, Australia

[2] Univ Western Australia, Sch Paediat & Child Hlth, Perth, WA 6872, Australia

[3] Murdoch Univ, Div Hlth Sci, Perth, WA 6150, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2007年 / 85卷 / 03期

关键词：

airway; antigen; dendritic cell; lung; mouse; CD4(+) T-CELLS; INFLUENZA-VIRUS INFECTION; TIGHT JUNCTION PROTEINS; LYMPH-NODE; IN-VIVO; B-CELLS; CONDUCTING AIRWAYS; PRIMARY RESPONSE; HOST-DEFENSE; LUNG;

D O I：

10.1038/sj.icb.7100039

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is widely accepted that tissue dendritic cells (DC) function as immune sentinels by alerting T cells to foreign antigen after delivering and presenting it in the draining lymph nodes. Over the last two decades, studies in animal models, particularly rodents, have demonstrated that respiratory tract DC are crucial for the adaptive immune response to inhaled antigen. Indeed, the fate of inhaled antigen is inextricably linked to the function of respiratory tract DC. In this review, we will discuss the characteristics of respiratory tract DC from mice and recent data that may help to explain their role in the fate of inhaled antigen.

引用

页码：182 / 188

页数：7

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