Efficient enantioselective synthesis of piperidines through catalytic asymmetric ring-opening/cross-metathesis reactions

被引：69

作者：

Cortez, G. Alex

Schrock, Richard R.

Hoveyda, Amir H. ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

asymmetric catalysis; molybdenum; olefin metathesis; piperidines; ruthenium;

D O I：

10.1002/anie.200605130

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mo the better! Chiral Mo complexes promote highly efficient asymmetric ring-opening/cross-metathesis reactions that afford functionalized piperidines in high E:Z selectivity and enantiomeric purity (see scheme for example; TBS = tert-butyldimethylsilyl). In most cases, Ru catalysts are ineffective. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：4534 / 4538

页数：5

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