In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

被引：33

作者：

Begum, K

Kim, HS

Kumar, V

Stojiljkovic, I

Wataya, Y ^{[1
]}

机构：

[1] Okayama Univ, Dept Drug Informat, Fac Pharmaceut Sci, Okayama 7008530, Japan

[2] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

PARASITOLOGY RESEARCH | 2003年 / 90卷 / 03期

关键词：

D O I：

10.1007/s00436-003-0830-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The in vitro antimalarial activity against Plasmodium falciparum and heme polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 muM to 190 muM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

引用

收藏

页码：221 / 224

页数：4

相关论文

共 24 条

[1] Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation [J].

Basilico, N ;

Monti, D ;

Olliaro, P ;

Taramelli, D .

FEBS LETTERS, 1997, 409 (02) :297-299

[2] FERRIPROTOPORPHYRIN-IX FULFILLS THE CRITERIA FOR IDENTIFICATION AS THE CHLOROQUINE RECEPTOR OF MALARIA PARASITES [J].

CHOU, AC ;

CHEVLI, R ;

FITCH, CD .

BIOCHEMISTRY, 1980, 19 (08) :1543-1549

[3] Metalloporphyrins inhibit β-hematin (hemozoin) formation [J].

Cole, KA ;

Ziegler, J ;

Evans, CA ;

Wright, DW .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 78 (02) :109-115

[4] OXIDATIVE CLEAVAGE OF DNA MEDIATED BY HYBRID METALLOPORPHYRIN ELLIPTICINE MOLECULES AND FUNCTIONALIZED METALLOPORPHYRIN PRECURSORS [J].

DING, L ;

ETEMADMOGHADAM, G ;

MEUNIER, B .

BIOCHEMISTRY, 1990, 29 (34) :7868-7875

[5] MALARIAL HAEMOZOIN BETA-HEMATIN SUPPORTS HEME POLYMERIZATION IN THE ABSENCE OF PROTEIN [J].

DORN, A ;

STOFFEL, R ;

MATILE, H ;

BUBENDORF, A ;

RIDLEY, RG .

NATURE, 1995, 374 (6519) :269-271

[6] QUINOLINE ANTIMALARIAL-DRUGS INHIBIT SPONTANEOUS FORMATION OF BETA-HEMATIN (MALARIA PIGMENT) [J].

EGAN, TJ ;

ROSS, DC ;

ADAMS, PA .

FEBS LETTERS, 1994, 352 (01) :54-57

[7] Hemoglobin metabolism in the malaria parasite Plasmodium falciparum [J].

Francis, SE ;

Sullivan, DJ ;

Goldberg, DE .

ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 :97-123

[8] Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action [J].

Ginsburg, H ;

Famin, O ;

Zhang, JM ;

Krugliak, M .

BIOCHEMICAL PHARMACOLOGY, 1998, 56 (10) :1305-1313

[9] HEMOGLOBIN DEGRADATION IN THE MALARIA PARASITE PLASMODIUM-FALCIPARUM - AN ORDERED PROCESS IN A UNIQUE ORGANELLE [J].

GOLDBERG, DE ;

SLATER, AFG ;

CERAMI, A ;

HENDERSON, GB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :2931-2935

[10] Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes [J].

Kim, HS ;

Nagai, Y ;

Ono, K ;

Begum, K ;

Wataya, Y ;

Hamada, Y ;

Tsuchiya, K ;

Masuyama, A ;

Nojima, M ;

McCullough, KJ .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (14) :2357-2361