Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system

被引:321
作者
Kageyama, R
Nakanishi, S
机构
[1] Department of Biological Sciences, Kyoto Univ. Faculty of Medicine, 606, Yoshida, Sakyo-ku, Kyoto
关键词
D O I
10.1016/S0959-437X(97)80014-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Neural development involves the initial growth phase of dividing precursor cells and the subsequent differentiation phase of postmitotic cells. Recent studies indicate that the transition from the former phase to the latter is controlled antagonistically by multiple helix-loop-helix (HLH) genes. Cascades of neuronal HLH genes promote differentiation whereas anti-neuronal HLH genes repress them under the control of Notch and keep cells at the precursor stage. This antagonistic regulation may be essential for generation of the proper number of neurons and for morphogenesis of the nervous system.
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页码:659 / 665
页数:7
相关论文
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