The role of long-lived plasma cells in autoimmunity -: Review

被引：17

作者：

Arce, S

Cassese, G

Hauser, A

Dörner, T

Odendahl, M

Manz, R

Radbruch, A

Hiepe, F

机构：

[1] German Rheumatism Res Ctr, Berlin, Germany

[2] Humboldt Univ, Hosp Charite, Dept Med Rheumatol & Clin Immunol, Berlin, Germany

来源：

IMMUNOBIOLOGY | 2002年 / 206卷 / 05期

关键词：

D O I：

10.1078/0171-2985-00204

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.Recent results on the biology of plasma cells have shown that these cells can survive as long as memory B cells. Possibly, such long-lived plasma cells are also involved in the production of autoantibodies. Here, we discuss the potential involvement of long-lived plasma cells in the pathogenesis of autoimmune disease and the consequences it has for the development of effective therapeutic strategies.

引用

页码：558 / 562

页数：5

共 31 条

[1] Immunological memory and protective immunity: Understanding their relation [J].