Synthesis of the first enantiomerically pure 3-thiazolines via Asinger reaction

被引：26

作者：

Schlemminger, I ^{[1
]}

Janknecht, HH ^{[1
]}

Maison, W ^{[1
]}

Saak, W ^{[1
]}

Martens, J ^{[1
]}

机构：

[1] Carl von Ossietzky Univ Oldenburg, Dept Chem, D-26111 Oldenburg, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 38期

关键词：

Asinger reaction; imines; thiazolines; enantioselection;

D O I：

10.1016/S0040-4039(00)01266-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of an enantiomerically and diastereomerically pure 3-thiazoline via modified Asinger reaction using a galactose derived chiral auxiliary is described. The absolute configuration of this heterocyclic imine has been elucidated via X-ray analysis. In addition, the 3-thiazoline has been successfully derivatized under Ugi conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7289 / 7292

页数：4

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