Histone deacetylases-an important class of cellular regulators with a variety of functions

被引：153

作者：

Hildmann, Christian ^{[1
]}

Riester, Daniel ^{[1
]}

Schwienhorst, Andreas ^{[1
]}

机构：

[1] Inst Genet & Microbiol, Dept Mol Genet & Preparat Mol Biol, D-37077 Gottingen, Germany

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2007年 / 75卷 / 03期

关键词：

D O I：

10.1007/s00253-007-0911-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The elucidation of mechanisms of chromatin remodeling, particular transcriptional activation, and repression by histone acetylation and deacetylation has shed light on the role of historic deacetylases (HDAC) as a new kind of therapeutic target for human cancer treatment. HDACs, in general, act as components of large corepressor complexes that prevent the transcription of several tumor suppression genes. In addition, they appear to be also involved in the deacetylation of nonhistone proteins. This paper reviews the most recent insights into the diverse biological roles of HDACs as well as the evolution of this important protein family.

引用

页码：487 / 497

页数：11

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