TIM-3 as a therapeutic target in human inflammatory diseases

被引：28

作者：

Anderson, David E.

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2007年 / 11卷 / 08期

关键词：

autoimmune disease; cancer; inflammation; TIM-3; tolerance;

D O I：

10.1517/14728222.11.8.1005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) was the first, and is presently the only, surface molecule that can specifically identify T(H)1 cells in both mice and humans. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear.

引用

页码：1005 / 1009

页数：5

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