Modification of dopamine release by nociceptin in conscious rat striatum

被引：32

作者：

Konya, H

Masuda, H

Itoh, K

Nagai, K

Kakishita, E

Matsuoka, A

机构：

[1] Hyogo Coll Med, Dept Clin Labs, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Coll Med, Dept Pharmacol, Nishinomiya, Hyogo 6638501, Japan

[3] Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan

[4] Hyogo Coll Med, Dept Clin Pathol, Nishinomiya, Hyogo 6638501, Japan

来源：

BRAIN RESEARCH | 1998年 / 788卷 / 1-2期

关键词：

nociceptin; orphanin FQ; microdialysis; striatum; dopamine; naloxone;

D O I：

10.1016/S0006-8993(98)00075-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nociceptin (NOC), an endogenous ligand for the orphan receptor ORL1, has recently been recognized as a neuropeptide. We used brain microdialysis and on-line high performance liquid chromatography to examine the effect of NOC on the basal outflow of dopamine (DA) and its metabolite in the freely moving rat striatum in vivo. The percent change of DA release induced by NOC at concentrations of 10(-6) and 10(-5) M were 383% and 398%, respectively. This effect of NOC was attenuated by naloxone, suggesting that NOC activates classic (mu, delta, kappa) receptors in a very little way. These data indicates that NOC may act as a neuropeptide which enhances DA release from the striatum of rat brain via an opioid receptor. (C) 1998 Elsevier Science B.V.

引用

页码：341 / 344

页数：4

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