Plasma effects on subcellular structures

被引：38

作者：

Gweon, Bomi ^{[2
]}

Kim, Daeyeon ^{[1
]}

Kim, Dan Bee ^{[2
]}

Jung, Heesoo ^{[2
]}

Choe, Wonho ^{[2
]}

Shin, Jennifer H. ^{[1
,3
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Mech Engn, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Phys, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea

来源：

APPLIED PHYSICS LETTERS | 2010年 / 96卷 / 10期

关键词：

OXIDATIVE STRESS; CELLS;

D O I：

10.1063/1.3352316

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Atmospheric pressure helium plasma treated human hepatocytes exhibit distinctive zones of necrotic and live cells separated by a void. We propose that plasma induced necrosis is attributed to plasma species such as oxygen radicals, charged particles, metastables and/or severe disruption of charged cytoskeletal proteins. Interestingly, uncharged cytoskeletal intermediate filaments are only minimally disturbed by plasma, elucidating the possibility of plasma induced electrostatic effects selectively destroying charged proteins. These bona fide plasma effects, which inflict alterations in specific subcellular structures leading to necrosis and cellular detachment, were not observed by application of helium flow or electric field alone. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3352316]

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