Synthesis and biological activity of esters in the trans-1,2-dihydroxy-1,2-dihydroacronycine series

被引：25

作者：

Magiatis, P

Mitaku, S

Skaltsounis, AL ^{[1
]}

Tillequin, F

Koch, M

Pierré, A

Atassi, G

机构：

[1] Univ Athens, Lab Pharmacognosy, GR-15771 Athens, Greece

[2] Univ Paris 05, Fac Sci Pharmaceut & Biol, Lab Pharmacognosie, CNRS,URA 1310, F-75006 Paris, France

[3] Inst Rech Servier, F-92150 Suresnes, France

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 02期

关键词：

D O I：

10.1021/np970427s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Permanganate oxidation of acronycine (1) led to keto alcohol 4 which could be reduced to trans-1,2-dihydroxy-1,2-dihydroacronycine (3) using NaBH4. Acylation of 3 afforded 12, 13, and 14. These esters (12, 13, and 14) were more potent than 1 when tested against L-1210 cells in vitro. Diacetate 12 was evaluated in vivo against murine P-388 leukemia and was markedly active at a dose 16-fold lower than acronycine itself. Comparison of these results with those recently obtained in the cis-1,2-dihydroxy-1,2-dihydroacronycine series is discussed.

引用

页码：198 / 201

页数：4

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