Dual action-based approaches to antibacterial agents

被引：80

作者：

Bremner, John B. ^{[1
]}

Ambrus, Joseph I.

Samosorn, Siritron

机构：

[1] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[2] Srinakharinwirot Univ, Dept Chem, Bangkok, Thailand

来源：

CURRENT MEDICINAL CHEMISTRY | 2007年 / 14卷 / 13期

关键词：

dual action antibacterials; bacterial resistance; dual action drugs; dual action prodrugs;

D O I：

10.2174/092986707780831168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review collates and analyses recent work done on dual action approaches to tackling the mounting health problem of resistance by human pathogenic bacteria to antibacterial agents. In particular the areas reviewed include the use of two drugs in combination, dual action prodrugs, and dual action drugs (or hybrid drugs).

引用

页码：1459 / 1477

页数：19

共 52 条

[1] DUAL-ACTION CEPHALOSPORINS - CEPHALOSPORIN 3'-QUATERNARY AMMONIUM QUINOLONES [J].

ALBRECHT, HA ;

BESKID, G ;

CHRISTENSON, JG ;

DURKIN, JW ;

FALLAT, V ;

GEORGOPAPADAKOU, NH ;

KEITH, DD ;

KONZELMANN, FM ;

LIPSCHITZ, ER ;

MCGARRY, DH ;

SIEBELIST, J ;

WEI, CC ;

WEIGELE, M ;

YANG, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :669-675

[2] CEPHALOSPORIN 3'-QUINOLONE ESTERS WITH A DUAL MODE OF ACTION [J].

ALBRECHT, HA ;

BESKID, G ;

CHAN, KK ;

CHRISTENSON, JG ;

CLEELAND, R ;

DEITCHER, KH ;

GEORGOPAPADAKOU, NH ;

KEITH, DD ;

PRUESS, DL ;

SEPINWALL, J ;

SPECIAN, AC ;

THEN, RL ;

WEIGELE, M ;

WEST, KF ;

YANG, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :77-86

[3] DUAL-ACTION CEPHALOSPORINS - CEPHALOSPORIN 3'-QUINOLONE CARBAMATES [J].

ALBRECHT, HA ;

BESKID, G ;

CHRISTENSON, JG ;

GEORGOPAPADAKOU, NH ;

KEITH, DD ;

KONZELMANN, FM ;

PREUSS, DL ;

ROSSMAN, PL ;

WEI, CC .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) :2857-2864

[4] DUAL-ACTION CEPHALOSPORINS INCORPORATING A 3'-TERTIARY-AMINE-LINKED QUINOLONE [J].

ALBRECHT, HA ;

BESKID, G ;

CHRISTENSON, JG ;

DEITCHER, KH ;

GEORGOPAPADAKOU, NH ;

KEITH, DD ;

KONZELMANN, FM ;

PRUESS, DL ;

WEI, CC .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (03) :400-407

[5] Is in vitro antibiotic combination more effective than single-drug therapy against anthrax? [J].

Athamna, A ;

Athamna, M ;

Nura, A ;

Shlyakov, E ;

Bast, DJ ;

Farrell, D ;

Rubinstein, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (04) :1323-1325

[6] Conjugating berberine to a multidrug resistance pump inhibitor creates an effective antimicrobial [J].

Ball, Anthony R. ;

Casadei, Gabriele ;

Samosorn, Siritron ;

Bremner, John B. ;

Ausubel, Frederick M. ;

Moy, Terence I. ;

Lewis, Kim .

ACS CHEMICAL BIOLOGY, 2006, 1 (09) :594-600

[7] Potent algicides based on the cyanobacterial alkaloid nostocarboline [J].

Blom, JF ;

Brütsch, T ;

Barbaras, D ;

Bethuel, Y ;

Locher, HH ;

Hubschwerlen, C ;

Gademann, K .

ORGANIC LETTERS, 2006, 8 (04) :737-740

[8]

Bryskier A, 2005, ANTIMICROBIAL AGENTS: ANTIBACTERIALS AND ANTIFUNGALS, P1

[9] Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia [J].

Chamot, E ;

El Amari, EB ;

Rohner, P ;

Van Delden, C .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (09) :2756-2764

[10] Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: a commentary [J].

Chow, JW ;

Yu, VL .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1999, 11 (01) :7-12

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