Protein fold recognition without Boltzmann statistics or explicit physical basis

被引：18

作者：

Huber, T ^{[1
]}

Torda, AE ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

来源：

PROTEIN SCIENCE | 1998年 / 7卷 / 01期

关键词：

fold recognition; low-resolution force field; optimization algorithm; parameter determination; threading;

D O I：

10.1002/pro.5560070115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a fast method for finding optimal parameters for a low-resolution (threading) force field intended to distinguish correct from incorrect folds for a given protein sequence. In contrast to other methods, the parameterization uses information from >10(7) misfolded structures as well as a set of native sequence-structure pairs. In addition to testing the resulting force field's performance on the protein sequence threading problem, results are shown that characterize the number of parameters necessary for effective structure recognition.

引用

页码：142 / 149

页数：8

共 37 条

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