Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats

被引：186

作者：

de Lima, MNM

Laranja, DC

Bromberg, E

Roesler, R

Schröder, N

机构：

[1] Catholic Univ, PUCRS, Biosci Fac, Memory & Neurodegenerat Lab,Dept Physiol Sci, BR-90619900 Porto Alegre, RS, Brazil

[2] Catholic Univ, PUCRS, Grad Program Biomed Gerontol, IGG,Sao Lucas Hosp, BR-90619900 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande Sul, Inst Basic Hlth Sci, Dept Pharmacol, Preclin Neuropharmacol Lab, BR-90046900 Porto Alegre, RS, Brazil

来源：

BEHAVIOURAL BRAIN RESEARCH | 2005年 / 156卷 / 01期

关键词：

MK-801; NMDA receptor; neural plasticity; recognition memory;

D O I：

10.1016/j.bbr.2004.05.016

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The aim of the present study was to investigate the effects of NMDA receptor blockade on formation of object recognition memory. In the first experiment, adult Wistar rats were given an intraperitoneal injection of saline or the NMDA receptor antagonist [(+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclo-hepten-5,10-imine-maleate] (MK-801) (0.001, 0.01, or 0.1 mg/kg) 20 min prior to training in a novel object recognition task. In the second experiment, saline or MK-801 (0.1 mg/kg) were given immediately after training. Memory retention was tested 1.5 and 24 h after training. MK-801 impaired both short- and long-term retention of object recognition memory when given either before or after training. The results suggest that NMDA receptor activation is necessary for formation of object recognition memory. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：139 / 143

页数：5

共 46 条

[1] A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat [J].

Åhlander, M ;

Misane, I ;

Schött, PA ;

Ögren, SO .

NEUROPSYCHOPHARMACOLOGY, 1999, 21 (03) :414-426

[2] Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats [J].

Baker, KB ;

Kim, JJ .

LEARNING & MEMORY, 2002, 9 (02) :58-65

[3] EFFECTS OF INTRAVENTRICULAR INFUSION OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST AP5 ON SPATIAL MEMORY OF RATS IN A RADIAL ARM MAZE [J].

BOLHUIS, JJ ;

REID, IC .

BEHAVIOURAL BRAIN RESEARCH, 1992, 47 (02) :151-157

[4] A NOVEL NMDA ANTAGONIST, MK-801, IMPAIRS PERFORMANCE IN A HIPPOCAMPAL-DEPENDENT SPATIAL-LEARNING TASK [J].

BUTELMAN, ER .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 34 (01) :13-16

[5] SPATIAL MEMORY AND N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS APV AND MK-801 - MEMORY IMPAIRMENTS DEPEND ON FAMILIARITY WITH THE ENVIRONMENT, DRUG DOSE, AND TRAINING DURATION [J].

CARAMANOS, Z ;

SHAPIRO, ML .

BEHAVIORAL NEUROSCIENCE, 1994, 108 (01) :30-43

[6] NMDA receptors and learning and memory processes [J].

Castellano, C ;

Cestari, V ;

Ciamei, A .

CURRENT DRUG TARGETS, 2001, 2 (03) :273-283

[7] MK-801-induced disruptions of one-trial inhibitory avoidance are potentiated by stress and reversed by naltrexone [J].

Castellano, C ;

Cestari, V ;

Ciamei, A ;

Pavone, F .

NEUROBIOLOGY OF LEARNING AND MEMORY, 1999, 72 (03) :215-229

[8] Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice [J].

Ciamei, A ;

Aversano, M ;

Cestari, V ;

Castellano, C .

PSYCHOPHARMACOLOGY, 2001, 154 (02) :126-130

[9] CONTRASTING EFFECTS OF THE COMPETITIVE NMDA ANTAGONIST CPP AND THE NONCOMPETITIVE NMDA ANTAGONIST MK-801 ON PERFORMANCE OF AN OPERANT DELAYED MATCHING TO POSITION TASK IN RATS [J].

COLE, BJ ;

KLEWER, M ;

JONES, GH ;

STEPHENS, DN .

PSYCHOPHARMACOLOGY, 1993, 111 (04) :465-471

[10] Comparison of various N-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour [J].

Doyle, KM ;

Feerick, S ;

Kirkby, DL ;

Eddleston, A ;

Higgins, GA .

BEHAVIOURAL PHARMACOLOGY, 1998, 9 (08) :671-681

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