Effect of influenza vaccination on the prognosis of hospitalized influenza patients

被引：40

作者：

Casado, Itziar ^{[1
]}

Dominguez, Angela ^{[2
,3
]}

Toledo, Diana ^{[3
]}

Chamorro, Judith ^{[4
]}

Force, Lluis ^{[5
]}

Soldevila, Nuria ^{[2
,3
]}

Astray, Jenaro ^{[6
]}

Egurrola, Mikel ^{[7
]}

Godoy, Pere ^{[2
,8
,9
]}

Mayoral, Jose M. ^{[10
]}

Tamames, Sonia ^{[11
]}

Sanz, Francisco ^{[12
]}

Castilla, Jess ^{[1
,2
]}

机构：

[1] IdiSNA Navarra Inst Hlth Res, Inst Salud Publ Navarra, Pamplona, Spain

[2] CIBERESP, Madrid, Spain

[3] Univ Barcelona, Dept Salut Publ, Barcelona, Spain

[4] Complejo Hosp Navarra, Serv Med Prevent, Pamplona, Spain

[5] Hosp Mataro, Unidad Enfermedades Infecciosas, Mataro, Spain

[6] Consejeria Sanidad, Direcc Salud Publ, Madrid, Spain

[7] Hosp Galdakao, Serv Neumol, Usansolo, Spain

[8] Agencia Salut Publ Catalunya, Barcelona, Spain

[9] Univ Lleida, Inst Recerca Biomed Lleida, Lleida, Spain

[10] Junta Andalucia, Serv Vigilancia, Seville, Spain

[11] Direcc Gen Salud Publ Invest Desarrollo & Innovac, Valladolid, Spain

[12] Univ Valencia, Consorci Hosp Gen, Serv Neumol, Valencia, Spain

来源：

EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 03期

关键词：

mortality; severe influenza; vaccine effectiveness; seasonal influenza vaccine; Influenza virus; LABORATORY-CONFIRMED INFLUENZA; 2012-2013; SEASON; SEVERITY; ADULTS; INDIVIDUALS; OUTPATIENT; MORTALITY; VIRUS; SPAIN; RISK;

D O I：

10.1586/14760584.2016.1134328

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Objectives: This study aimed to assess whether influenza vaccination reduces the risk of severe and fatal outcomes in influenza inpatients aged >= 65years. Methods: During the 2013-2014 influenza season persons aged >= 65years hospitalized with laboratory-confirmed influenza were selected in 19 Spanish hospitals. A severe influenza case was defined as admission to the intensive care unit, death in hospital or within 30 days after admission. Logistic regression was used to compare the influenza vaccination status between severe and non-severe influenza inpatients. Results: Of 433 influenza confirmed patients, 81 (19%) were severe cases. Vaccination reduced the risk of severe illness (odds ratio: 0.57; 95%CI: 0.33-0.98). The cumulative number of influenza vaccine doses received since the 2010-2011 season was associated with a lower risk of severe influenza (odds ratio: 0.78; 95% CI 0.66-0.91). Conclusion: Adherence to seasonal influenza vaccination in the elderly may reduce the risk of severe influenza outcomes.

引用

页码：425 / 432

页数：8

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