Low ethanol consumption increases insulin sensitivity in Wistar rats

被引:38
作者
Furuya, DT [1 ]
Binsack, R [1 ]
Machado, UF [1 ]
机构
[1] Univ Sao Paulo, Dept Fisiol & Biofis, BR-05508900 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
insulin sensitivity; ethanol; live glycogen; low ethanol consumption;
D O I
10.1590/S0100-879X2003000100017
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Several human studies suggest that light-to-moderate alcohol consumption is associated with enhanced insulin sensitivity, but these studies are not free of conflicting results. To determine if ethanol-enhanced insulin sensitivity could be demonstrated in an animal model, male Wistar rats were fed a standard chow diet and received drinking water without (control) or with different ethanol concentrations (0.5, 1.5, 3, 4.5 and 7%, v/v) for 4 weeks ad libitum. Then, an intravenous insulin tolerance test (IVITT) was performed to determine insulin sensitivity. Among the ethanol groups, only the 3% ethanol group showed an increase in insulin sensitivity based on the increase of the plasma glucose disappearance rate in the IVITT (30%, P<0.05). In addition, an intravenous glucose tolerance test (IVGTT) was performed in control and 3% ethanol animals. Insulin sensitivity was confirmed in 3% ethanol rats based on the reduction of insulin secretion in the IVGTT (35%, P<0.05), despite the same glucose profile. Additionally, the 3% ethanol treatment did not impair body weight gain or plasma aspartate aminotransferase and alanine aminotransferase activities. Thus, the present study established that 3% ethanol in the drinking water for 4 weeks in normal rats is a model of increased insulin sensitivity, which can be used for further investigations of the mechanisms involved.
引用
收藏
页码:125 / 130
页数:6
相关论文
共 20 条
[1]  
AlQatari M, 1996, ALCOHOL ALCOHOLISM, V31, P89
[2]   Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors - The insulin resistance and atherosclerosis study [J].
Bell, RA ;
Mayer-Davis, EJ ;
Martin, MA ;
D'Agostino, RB ;
Haffner, SM .
DIABETES CARE, 2000, 23 (11) :1630-1636
[3]  
Binsack R, 1999, FREE RADICAL BIO MED, V27, pS72
[4]   ESTIMATES OF INVIVO INSULIN ACTION IN MAN - COMPARISON OF INSULIN TOLERANCE-TESTS WITH EUGLYCEMIC AND HYPERGLYCEMIC GLUCOSE CLAMP STUDIES [J].
BONORA, E ;
MOGHETTI, P ;
ZANCANARO, C ;
CIGOLINI, M ;
QUERENA, M ;
CACCIATORI, V ;
CORGNATI, A ;
MUGGEO, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (02) :374-378
[6]   One for the heart [J].
Doll, R .
BRITISH MEDICAL JOURNAL, 1997, 315 (7123) :1664-1668
[7]   MORTALITY IN RELATION TO CONSUMPTION OF ALCOHOL - 13 YEARS OBSERVATIONS ON MALE BRITISH DOCTORS [J].
DOLL, R ;
PETO, R ;
HALL, E ;
WHEATLEY, K ;
GRAY, R .
BRITISH MEDICAL JOURNAL, 1994, 309 (6959) :911-918
[8]   LIGHT-TO-MODERATE ALCOHOL INTAKE IS ASSOCIATED WITH ENHANCED INSULIN SENSITIVITY [J].
FACCHINI, F ;
CHEN, YDI ;
REAVEN, GM .
DIABETES CARE, 1994, 17 (02) :115-119
[9]   Type of alcoholic beverage and risk of myocardial infarction [J].
Gaziano, JM ;
Hennekens, CH ;
Godfried, SL ;
Sesso, HD ;
Glynn, RJ ;
Breslow, JL ;
Buring, JE .
AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (01) :52-57
[10]  
Kannel WB, 1996, CLIN CHIM ACTA, V246, P59