Histological localization of phosphorothioate oligodeoxynucleotides in normal rodent tissue

被引：12

作者：

Butler, M ^{[1
]}

Stecker, K ^{[1
]}

Bennett, CF ^{[1
]}

机构：

[1] ISIS PHARMACEUT,CARLSBAD,CA 92008

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006272

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distribution of phosphorothioate oligodeoxynucleotides (P=S ODN) in rodent tissues was studied in vivo using three histological methods: direct fluorescence microscopy; immunohistochemistry; and autoradiography. All three methods gave essentially the same pattern of oligonucleotide localization in the tissues studied, and the histological results correlate well with those from radiochemical and biochemical studies of P=S ODN distribution.

引用

页码：1761 / 1764

页数：4