Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid

被引:9
作者
Trollfors, B [1 ]
Taranger, J
Lagergård, T
Sundh, V
机构
[1] Sahlgrens Univ Hosp, Dept Pediat, S-41345 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Dept Med Microbiol & Immunol, S-41345 Gothenburg, Sweden
[3] Sahlgrens Univ Hosp, Dept Community Med, S-41345 Gothenburg, Sweden
[4] Univ Gothenburg, Gothenburg, Sweden
关键词
diphtheria; tetanus; pertussis; toxoid; interactions;
D O I
10.1097/01.inf.0000148929.91719.10
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of pertussis toxoid on the immunogenicity of diphtheria and tetanus toxoids (DT) was studied during a double blind efficacy trial of an acellular pertussis vaccine. Infants received DT with or without pertussis toxoid at 3, 5 and 12 months of age. Geometric mean concentrations were higher in the DT than in the DT-pertussis toxoid group 1 month (diphtheria toxoid 4.76 versus 3.58 IU/mL, P = 0.009; tetanus toxoid 4.42 versus 2.66 IU/mL. P < 0.0001) and 2 years after the third injection (diphtheria toxoid 0.15 versus 0.10 IU/mL, P < 0.0001; tetanus toxoid 0.38 versus 0.18 IU/mL, P < 0.0001). Pertussis toxoid causes a small but significant reduction of the immunogenicity of diphtheria toxoid and tetanus toxoid.
引用
收藏
页码:85 / 86
页数:2
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