Antibacterial steroidal alkaloids from Sarcococca saligna

被引：43

作者：

Atta-ur-Rahman ^{[1
]}

Anjum, S ^{[1
]}

Farooq, A ^{[1
]}

Khan, MR ^{[1
]}

Parveen, Z ^{[1
]}

Choudhary, MI ^{[1
]}

机构：

[1] Univ Karachi, Hej Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 02期

关键词：

D O I：

10.1021/np970294a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new pregnane-type steroidal alkaloids, saligcinnamide [(20S,2'E)-20-(N,N-dimethylamino)3 beta-(3'-phenyl-2'-propenyl-N-methylamido)] (1) and N-a-methyl epipachysamine-D[(20S)-20-(N,N-dimethylamino)-3 beta-(N-methylbenzamido)pregnane] (2), along with a known base, epipachysamine D [(20S)-20-(N,N-dimethylamino)-3 beta-(benzamido)pregnane] (3), were isolated from the EtOH extracts of the roots and stems of Sarcococca saligna. The new bases exhibited antibacterial activity against several human pathogenic bacteria. Two derivatives of 1, dihydrosaligcinnamide [(20S)-20-(N,N-dimethylamino)-3 beta-(3'-phenylpropionoyl-N-methylamido)pregnane] (4) and dihydrosaligcinnamine [(20S)-20-(N,N-dimethylamino)-3 beta-N-(3'-phenylpropyl-N- methylamino)pregnane] (5), and a derivative of 1, N-a-methyl epipachysamine [(20S)-20-(N,N-dimethylamino)-3 beta-(N-benzyl, N-methylamino)pregnane] (6) were prepared and their antibacterial activity determined.

引用

页码：202 / 206

页数：5

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