CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR and BBLB/c mice

被引：24

作者：

Signore, A

Annovazzi, A

Procaccini, E

Beales, PE

Spencer, J

Testi, R

Ruberti, G

机构：

[1] UNIV ROMA LA SAPIENZA,MED CLIN 2,NUMED GRP,ROME,ITALY

[2] ST BARTHOLOMEWS HOSP,DEPT DIABETES & METAB,LONDON,ENGLAND

[3] UMDS,ST THOMAS HOSP,LONDON,ENGLAND

[4] UNIV ROMA TOR VERGATA,DIPARTIMENTO MED SPERIMENTALE,ROME,ITALY

[5] CNR,INST CELL BIOL,DEPT IMMUNOBIOL,ROME,ITALY

来源：

DIABETOLOGIA | 1997年 / 40卷 / 12期

关键词：

apoptosis; CD95; CD95L; NOD mouse;

D O I：

10.1007/s001250050852

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The non-obese diabetic (NOD) mouse is widely used to study the pathogenesis of insulin-dependent diabetes mellitus, However, the mechanisms responsible for beta-cell destruction, in this model, are still poorly defined. The CD95/CD95L system among other effector systems has been implicated in beta-cell death, In this study we investigated in NOD, non-obese resistant (NOR) and Balb/c mice the expression of CD95 and CD95L in alpha and beta pancreatic cells by immunohistochemistry and immunofluorescence. We demonstrate that alpha cells in the islets of Langherans constitutively express CD95L forming a natural shield around beta cells.

引用

页码：1476 / 1479

页数：4

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