No association is found between the candidate genes of t-PA/plasminogen system and Japanese methamphetamine-related disorder - A collaborative study by the Japanese genetics initiative for drug abuse

被引：12

作者：

Iwata, N ^{[1
]}

Inada, T

Harano, M

Komiyama, T

Yamada, M

Sekine, Y

Iyo, M

Sora, I

Ujike, H

Ozaki, N

机构：

[1] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Psychiat & Psychobiol, Nagoya, Aichi, Japan

[3] Kurume Univ, Sch Med, Dept Neuropsychiat, Kurume, Fukuoka 830, Japan

[4] Natl Ctr Hosp Mental Nervous & Muscular Disorders, Natl Ctr Neurol & Psychiat, Kodaira, Tokyo, Japan

[5] Showa Univ, Sch Med, Karasuyama Hosp, Tokyo 142, Japan

[6] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 43131, Japan

[7] Chiba Univ, Grad Sch Med, Dept Psychiat, Chiba, Japan

[8] Tohoku Univ, Grad Sch Med, Dept Neurosci, Div Psychobiol, Sendai, Miyagi 980, Japan

[9] Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, Okayama, Japan

来源：

CURRENT STATUS OF DRUG DEPENDENCE / ABUSE STUDIES: CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY | 2004年 / 1025卷

关键词：

tissue-plasminogen activator; plasminogen activator inhibitor; plasminogen; methamphetamine; drug dependence; polymorphisms; association study;

D O I：

10.1196/annals.1316.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the central nervous system, tissue-plasminogen activator (t-PA)/plasmin system is involved in long-term synaptic plasticity and remodeling, and participates in rewarding effects of methamphetamine (MAP), by acutely regulating MAP-induced dopamine release in the nucleus accumbens. The aim of this study was to examine the relationships between the patients with MAP abusers/psychosis and the t-PA/plasminogen system genes. Subjects comprised 185 MAP abusers and 288 healthy controls. Four polymorphisms in the t-PA, plasminogen activator inhibitor, and plasminogen genes were examined in the present study. No significant differences were observed in each polymorphism between healthy controls and MAP abusers/psychosis. This study suggests that t-PA/plasminogen system is unlikely to he a major contributor to the substance abuse liability and/or the development of MAP psychosis.

引用

页码：34 / 38

页数：5

共 11 条

[1] Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data [J].