In vitro susceptibility of Aspergillus spp. clinical isolates to albendazole

被引：6

作者：

Berthet, N

Faure, O

Bakri, A

Ambroise-Thomas, P

Grillot, R

Brugère, JF ^{[1
]}

机构：

[1] Univ Grenoble 1, Fac Med & Pharm, Lab Interact Cellulaires Parasite Hote, F-38706 La Tronche, France

[2] CHU Grenoble, Serv Parasitol Mycol, F-38043 Grenoble, France

[3] Univ Grenoble 1, Fac Pharm, INSERM 008, Code GEPRA, F-38706 La Tronche, France

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 06期

关键词：

drug susceptibility; benzimidazole; antifungal;

D O I：

10.1093/jac/dkg245

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in vitro antifungal activity of albendazole, a benzimidazole widely used as an antihelmintic drug in humans, was investigated and assessed for its activity against Aspergillus spp. Forty-eight isolates, representing the most frequent species found in human pathology [Aspergillus fumigatus (n = 27), Aspergillus flavus (n = 10), Aspergillus terreus (n = 7), Aspergillus nidulans (n = 3) and Aspergillus niger (n = 1)], and one quality control strain (A. niger ATCC 9804 83435) were tested according to the NCCLS M38-P methodology for moulds. All the strains were susceptible to albendazole, with homogeneous MICs for each species; three strains were resistant to itraconazole.

引用

页码：1419 / 1422

页数：4

共 10 条

[1] beta-tubulin genes and the basis for benzimidazole sensitivity of the opportunistic fungus Cryptococcus neoformans [J].