Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-Dependent mechanism

被引：16

作者：

Kim, MP

Gaydos, CA

Wood, BJ

Hardick, JP

Zhang, YH

Wahl, LM

机构：

[1] Natl Inst Dent & Craniofacial Res, Immunopathol Sect, NIH, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 01期

关键词：

D O I：

10.1128/IAI.73.1.632-634.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exposure of human monocytes to Chlamydia pneumoniae resulted in a significant enhancement of matrix metalloproteinase (MMP) 1 and 9 production following stimulation with tumor necrosis factor alpha and granulocyte monocyte-colony stimulating factor. The effect of C pneumoniae on monocyte MMPs was mediated through the induction of prostaglandin E, These findings may have implications for atherosclerotic plaque rupture.

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页码：632 / 634

页数：3

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