Mitochondrial membrane permeabilization by HIV-1 Vpr

被引：28

作者：

Deniaud, A

Brenner, C

Kroemer, G

机构：

[1] Univ Versailles, CNRS, FRE 2445, F-78035 Versailles, France

[2] Inst Gustave Roussy, CNRS, UMR 8125, F-94805 Villejuif, France

来源：

MITOCHONDRION | 2004年 / 4卷 / 2-3期

关键词：

apoptosis; adenine nucleotide translocase; mitochondrion; Bcl-2; viral target;

D O I：

10.1016/j.mito.2004.06.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mitochondrion is a privileged target for apopotosis-modulatory proteins of viral origin. Thus, viral protein R (Vpr) can target mitochondria and induce apoptosis via a specific interaction with the permeability transition pore complex (PTPC). Vpr cooperates with the adenine nucleotide translocator (ANT) to form large conductance channels and to trigger all the hallmarks of mitochondrial membrane permeabilization (MMP). The Vpr/ANT interaction is direct, since it is abolished by the addition of a peptide corresponding to the Vpr binding site of ANT, ADP, ATP, o.r by Bcl-2. Accordingly, Vpr modulates MMP through direct structural and functional interactions with PTPC proteins. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

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收藏

页码：223 / 233

页数：11

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