Natriuretic peptides in unstable coronary artery disease

被引：51

作者：

Jernberg, T ^{[1
]}

James, S ^{[1
]}

Lindahl, B ^{[1
]}

Johnston, N ^{[1
]}

Stridsberg, M ^{[1
]}

Venge, P ^{[1
]}

Wallentin, L ^{[1
]}

机构：

[1] Uppsala Res Ctr, Uppsala, Sweden

来源：

EUROPEAN HEART JOURNAL | 2004年 / 25卷 / 17期

关键词：

natriuretic peptide; unstable angina; myocardial infarction; prognosis;

D O I：

10.1016/j.ehj.2004.06.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with unstable coronary artery disease (CAD), i.e., unstable angina or non-ST-elevation myocardial infarction, vary widely in clinical presentation, prognosis and response to treatment. To select appropriate therapy, early risk stratification has become increasingly important. This review focuses on the emerging rote of natriuretic peptides in the early assessment of patients with unstable CAD. We conclude that levels of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are strongly associated to mortality and the risk of future congestive heart failure, and carry important prognostic information independent from previously known risk factors in unstable CAD. There are some data indicating that these markers can also be helpful in the selection of appropriate therapy in these patients but further studies are needed. Before a routine use of BNP or NT-proBNP in unstable CAD can be recommended, the cost-effectiveness of adding these new markers to the currently routine markers and their impact on selection of treatment needs further evaluation. (C) 2004 Published by Elsevier Ltd on behalf of The European Society of Cardiology.

引用

页码：1486 / 1493

页数：8

共 47 条

[1] Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes [J].