Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

被引：3563

作者：

Kwan, Patrick ^{[1
]}

Arzimanoglou, Alexis ^{[2
,3
]}

Berg, Anne T. ^{[4
]}

Brodie, Martin J. ^{[5
]}

Hauser, W. Allen ^{[14
]}

Mathern, Gary ^{[6
]}

Moshe, Solomon L. ^{[7
,8
]}

Perucca, Emilio ^{[9
,10
]}

Wiebe, Samuel ^{[11
,12
]}

French, Jacqueline ^{[13
]}

机构：

[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Div Neurol, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hosp Lyon HCL, Inst Children & Adolescents Epilepsy IDEE, Lyon, France

[3] INSERM, U821, F-69008 Lyon, France

[4] No Illinois Univ, Dept Biol, De Kalb, IL USA

[5] Univ Glasgow, Western Infirm, Epilepsy Unit, Glasgow G11 6NT, Lanark, Scotland

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA

[7] Albert Einstein Coll Med, Saul R Korey Dept Neurol, Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA

[8] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA

[9] IRCCS C Mondino Fdn, Clin Trial Ctr, Inst Neurol, Pavia, Italy

[10] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy

[11] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[12] Hotchkiss Brain Inst, Calgary, AB, Canada

[13] NYU, Comprehens Epilepsy Ctr, New York, NY USA

[14] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

来源：

EPILEPSIA | 2010年 / 51卷 / 06期

关键词：

Epilepsy; Drug resistance; Refractory; Intractable; Definition; ILAE; QUALITY-OF-LIFE; FOLLOW-UP; INTRACTABLE EPILEPSY; ANTIEPILEPTIC DRUGS; REFRACTORY EPILEPSY; PERCEIVED IMPACT; LONG; CHILDHOOD; OUTCOMES; IDENTIFICATION;

D O I：

10.1111/j.1528-1167.2009.02397.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P>To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant epilepsy. The overall framework of the definition has two "hierarchical" levels: Level 1 provides a general scheme to categorize response to each therapeutic intervention, including a minimum dataset of knowledge about the intervention that would be needed; Level 2 provides a core definition of drug resistant epilepsy using a set of essential criteria based on the categorization of response (from Level 1) to trials of antiepileptic drugs. It is proposed as a testable hypothesis that drug resistant epilepsy is defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom. This definition can be further refined when new evidence emerges. The rationale behind the definition and the principles governing its proper use are discussed, and examples to illustrate its application in clinical practice are provided.

引用

页码：1069 / 1077

页数：9

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