Lack of association between schizophrenia and HLA DQB1 alleles in a Swedish sample

被引：13

作者：

Jonsson, EG ^{[1
]}

Zhang, F

Nimgaonkar, VL

Rudert, WA

Sedvall, GC

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden

[2] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Human Genet, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Pediat, Pittsburgh, PA 15213 USA

来源：

SCHIZOPHRENIA RESEARCH | 1998年 / 29卷 / 03期

关键词：

schizophrenia; HLA; HLA DQB1; association study; genetics;

D O I：

10.1016/S0920-9964(97)00104-7

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Three studies have reported a negative genetic association between schizophrenia and HLA DQB1*0602, an allele of the human leucocyte antigen (HLA) DQB1*06 gene, In a sample of ethnic all homogeneous Caucasians living in Sweden, the frequency of HLA DQB1 alleles in patients with schizophrenia (n = 124) was compared with that in a control group (n = 85). No significant differences were found. Together with previous investigations, the present study indicates that the reported genetic association of DQB1*0602 with schizophrenia may be limited to non-Caucasians. (C) 1998 Elsevier Science B.V.

引用

页码：293 / 296

页数：4

共 16 条

[1]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[2]

CHAKRABORTY R, 1992, AM J HUM GENET, V50, P145

[3] Multilocus genetics of schizophrenia [J].

Cloninger, CR .

CURRENT OPINION IN PSYCHIATRY, 1997, 10 (01) :5-10

[4] GPOWER: A general power analysis program [J].

Erdfelder, E ;

Faul, F ;

Buchner, A .

BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS, 1996, 28 (01) :1-11

[5] AUTOIMMUNITY IN SCHIZOPHRENIA - A REVIEW OF RECENT FINDINGS [J].

GANGULI, R ;

BRAR, JS ;

CHENGAPPA, KNR ;

YANG, ZW ;

NIMGAONKAR, VL ;

RABIN, BS .

ANNALS OF MEDICINE, 1993, 25 (05) :489-496

[6] DOPAMINE D2-RECEPTOR GENE POLYMORPHISMS IN SCANDINAVIAN CHRONIC-ALCOHOLICS [J].

GEIJER, T ;

NEIMAN, J ;

RYDBERG, U ;

GYLLANDER, A ;

JONSSON, E ;

SEDVALL, G ;

VALVERIUS, P ;

TERENIUS, L .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1994, 244 (01) :26-32

[7] LACK OF ASSOCIATION BETWEEN SCHIZOPHRENIA AND ALLELES IN THE DOPAMINE-D3 RECEPTOR GENE [J].

JONSSON, E ;

LANNFELT, L ;

SOKOLOFF, P ;

SCHWARTZ, JC ;

SEDVALL, G .

ACTA PSYCHIATRICA SCANDINAVICA, 1993, 87 (05) :345-349

[8] THE GENETICS OF SCHIZOPHRENIA - A CURRENT, GENETIC-EPIDEMIOLOGIC PERSPECTIVE [J].

KENDLER, KS ;

DIEHL, SR .

SCHIZOPHRENIA BULLETIN, 1993, 19 (02) :261-285

[9] PCR-LIS-SSCP (low ionic strength single-stranded conformation polymorphism) - A simple method for high-resolution allele typing of HLA-DRB1, -DQB1, and -DPB1 [J].

Maruya, E ;

Saji, H ;

Yokoyama, S .

GENOME RESEARCH, 1996, 6 (01) :51-57

[10] Further evidence for an association between schizophrenia and the HLA DQB1 gene locus [J].

Nimgaonkar, VL ;

Rudert, WA ;

Zhang, XR ;

Tsoi, WF ;

Trucco, M ;

Saha, N .

SCHIZOPHRENIA RESEARCH, 1995, 18 (01) :43-49

← 1 2 →