Aging and cancer cell biology, 2007

被引：32

作者：

Campisi, Judith ^{[1
]}

机构：

[1] Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Buck Inst Age Res, Novato, CA 94945 USA

来源：

AGING CELL | 2007年 / 6卷 / 03期

关键词：

apoptosis; metalloproteinase; p16/INK4a; p53; senescence; stem cell; P53; MICE;

D O I：

10.1111/j.1474-9726.2007.00292.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This Hot Topics review, the second in a new Aging Cell series, discusses articles published in the last year that have stimulated new ideas about the tangled relationship of aging to cancer cell biology. The year's highlights include reports on the ability of Mdm2 mutations to diminish risks of cancer in aging mice, on proliferative competition between oncogenic cells and bone marrow stem cells, and on the role of metalloproteinases in overcoming age-associated barriers to tumor invasion. Of particular interest were three articles showing that diminished activity of the tumor-suppressor gene p16/INK4a, while increasing the risk of cancer mortality, can lead to improved function in several varieties of age-sensitive stem cells.

引用

页码：261 / 263

页数：3

共 12 条

[1] Impaired DNA replication within progenitor cell pools promotes leukemogenesis [J].

Bilousova, G ;

Marusyk, A ;

Porter, CC ;

Cardiff, RD ;

DeGregori, J .

PLOS BIOLOGY, 2005, 3 (12) :2135-2147

[2] 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally [J].

García-Cao, I ;

García-Cao, M ;

Martín-Caballero, J ;

Criado, LM ;

Klatt, P ;

Flores, JM ;

Weill, JC ;

Blasco, MA ;

Serrano, M .

EMBO JOURNAL, 2002, 21 (22) :6225-6235

[3] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[4] Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a [J].

Janzen, Viktor ;

Forkert, Randolf ;

Fleming, Heather E. ;

Saito, Yoriko ;

Waring, Michael T. ;

Dombkowski, David M. ;

Cheng, Tao ;

DePinho, Ronald A. ;

Sharpless, Norman E. ;

Scadden, David T. .

NATURE, 2006, 443 (7110) :421-426

[5] p16INK4a induces an age-dependent decline in islet regenerative potential [J].

Krishnamurthy, Janakiraman ;

Ramsey, Matthew R. ;

Ligon, Keith L. ;

Torrice, Chad ;

Koh, Angela ;

Bonner-Weir, Susan ;

Sharpless, Norman E. .

NATURE, 2006, 443 (7110) :453-457

[6] Modulation of mammalian life span by the short isoform of p53 [J].

Maier, B ;

Gluba, W ;

Bernier, B ;

Turner, T ;

Mohammad, K ;

Guise, T ;

Sutherland, A ;

Thorner, M ;

Scrable, H .

GENES & DEVELOPMENT, 2004, 18 (03) :306-319

[7] Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging [J].

Matheu, A ;

Pantoja, C ;

Efeyan, A ;

Criado, LM ;

Martín-Caballero, J ;

Flores, JM ;

Klatt, P ;

Serrano, M .

GENES & DEVELOPMENT, 2004, 18 (22) :2736-2746

[8] Tumor suppression and normal aging in mice with constitutively high p53 activity [J].

Mendrysa, SM ;

O'Leary, KA ;

McElwee, MK ;

Michalowski, J ;

Eisenman, RN ;

Powell, DA ;

Perry, ME .

GENES & DEVELOPMENT, 2006, 20 (01) :16-21

[9] Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing [J].

Molofsky, Anna V. ;

Slutsky, Shalom G. ;

Joseph, Nancy M. ;

He, Shenghui ;

Pardal, Ricardo ;

Krishnamurthy, Janakiraman ;

Sharpless, Norman E. ;

Morrison, Sean J. .

NATURE, 2006, 443 (7110) :448-452

[10] The effects of aging on tumor growth and angiogenesis are tumor-cell dependent [J].

Reed, Mail J. ;

Karres, Nathan ;

Eyman, Daniel ;

Cruz, Abigail ;

Brekken, Rolf A. ;

Plymate, Stephen .

INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (04) :753-760

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