Linear and cyclic LFA-I and ICAM-1 peptides inhibit T cell adhesion and function

被引：48

作者：

Tibbetts, SA ^{[1
]}

Jois, DSS ^{[1
]}

Siahaan, TJ ^{[1
]}

Benedict, SH ^{[1
]}

Chan, MA ^{[1
]}

机构：

[1] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

来源：

PEPTIDES | 2000年 / 21卷 / 08期

关键词：

LFA-1; ICAM-1; T cells; intercellular adhesion; mixed lymphocyte reaction;

D O I：

10.1016/S0196-9781(00)00255-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Short peptides derived from functional proteins have been used in several instances to inhibit activity of the parent proteins. In some cases, stability and efficacy were found to be increased by cyclization of these peptides. Inhibition of interaction of the two cell adhesion counter receptors leukocyte function-associated antigen (LFA)-1 and intercellular adhesion molecule (ICAM)-1 is being studied as a method for modulating autoimmune diseases such as rheumatoid arthritis and for facilitating organ transplantation. Here, several 10-amino acid peptides derived from the contact domains of LFA-1 and ICAM-1 were evaluated for their ability to interfere with intercellular adhesion by T cells and to inhibit a more biologic, mixed lymphocyte reaction. Both linear and cyclic forms of the peptides were effective at inhibiting intercellular adhesion. Cyclic forms were effective at inhibiting T cell activation and proliferation in the mixed lymphocyte reaction. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1161 / 1167

页数：7

共 23 条

[1] BETA(2) (CD18) MUTATIONS ABOLISH LIGAND RECOGNITION BY I-DOMAIN INTEGRINS LFA-1 (ALPHA(L)BETA(2), CD11A/CD18) AND MAC-1 (ALPHA(M)BETA(2), CD11B/CD18) [J].