Postmenopausal estrogen use and Parkinson's disease with and without dementia

被引：117

作者：

Marder, K

Tang, MX

Alfaro, B

Mejia, H

Cote, L

Jacobs, D

Stern, Y

Sano, M

Mayeux, R

机构：

[1] Gertrude H Sergievsky Ctr, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA

[3] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA

[4] Columbia Univ, Sch Publ Hlth, Div Epidemiol, New York, NY USA

[5] Columbia Univ, Sch Publ Hlth, Div Biostat, New York, NY 10032 USA

来源：

NEUROLOGY | 1998年 / 50卷 / 04期

关键词：

D O I：

10.1212/WNL.50.4.1141

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the effects of estrogen replacement therapy (ERT) on the risk of development of dementia in 87 women with Parkin son's disease without dementia (PDND), 80 women with Parkinson's disease with dementia (PDD), and 989 nondemented healthy women from the same community. ERT was protective for the development of dementia within the setting of PD (OR 0.22, 95% CI 0.05-1.0) and when PDD patients were compared with controls (OR 0.24, 95% CI 0.07-0.78), but did not affect the risk of PD. The results of the study suggest that a randomized clinical trial of ERT may be warranted.

引用

页码：1141 / 1143

页数：3

共 10 条

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