Vaccines in the era of genomics: The pneumococcal challenge

被引:65
作者
Barocchi, Michele Anne [1 ]
Censini, Stefano [1 ]
Rappuoli, Rino [1 ]
机构
[1] Novartis Vaccines, I-53100 Siena, Italy
关键词
Streptococcus pneumoniae; genomics; pangenome; reverse vaccinology; global vaccine;
D O I
10.1016/j.vaccine.2007.01.065
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this review we aim to provide the reader with an understanding of the capsular-based complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine development. We then discuss the need for a new vaccine strategy based on proteic antigen candidates discovered in silico. Describing specifically how reverse vaccinology coupled to conventional vaccinology has led to a new paradigm of vaccine development. Finally, we conclude with the importance of defining the pan-genome of the pneumococcus, that is, the sequencing and analysis of multiple genomes from the same species. A critical factor in determining conserved proteins in a group of epidemiologically relevant circulating S. pneumoniae strains, in order to achieve the greatest coverage. Ultimately, the identification of immunogenic surface antigens and assessment of their efficacy will be imperative in the development of a vaccine with the ability to protect against invasive disease independent of serotype. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2963 / 2973
页数:11
相关论文
共 98 条
[1]   Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis [J].
Adamou, JE ;
Heinrichs, JH ;
Erwin, AL ;
Walsh, W ;
Gayle, T ;
Dormitzer, M ;
Dagan, R ;
Brewah, YA ;
Barren, P ;
Lathigra, R ;
Langermann, S ;
Koenig, S ;
Johnson, S .
INFECTION AND IMMUNITY, 2001, 69 (02) :949-958
[2]   IMMUNIZATION OF MICE WITH PNEUMOLYSIN TOROID CONFERS A SIGNIFICANT DEGREE OF PROTECTION AGAINST AT LEAST 9 SEROTYPES OF STREPTOCOCCUS-PNEUMONIAE [J].
ALEXANDER, JE ;
LOCK, RA ;
PEETERS, CCAM ;
POOLMAN, JT ;
ANDREW, PW ;
MITCHELL, TJ ;
HANSMAN, D ;
PATON, JC .
INFECTION AND IMMUNITY, 1994, 62 (12) :5683-5688
[3]   Intradermal immunization of mice with cholera toxin B-pneumococcal surface protein A fusion protein is protective against intraperitoneal challenge with Streptococcus pneumoniae [J].
Arêas, APM ;
Oliveira, MLS ;
Miyaji, EN ;
Leite, LCC ;
Ho, PL .
INFECTION AND IMMUNITY, 2005, 73 (06) :3810-3813
[4]   Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae [J].
Balachandran, P ;
Brooks-Walter, A ;
Virolainen-Julkunen, A ;
Hollingshead, SK ;
Briles, DE .
INFECTION AND IMMUNITY, 2002, 70 (05) :2526-2534
[5]   A pneumococcal pilus influences virulence and host inflammatory responses [J].
Barocchi, MA ;
Rie, J ;
Zogaj, X ;
Hemsley, C ;
Albiger, B ;
Kanth, A ;
Dahlberg, S ;
Fernebro, J ;
Moschioni, M ;
Masignani, V ;
Hultenby, K ;
Taddei, AR ;
Beiter, K ;
Wartha, F ;
von Euler, A ;
Covacci, A ;
Holden, DW ;
Normark, S ;
Rappuoli, R ;
Henriques-Normark, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2857-2862
[6]   Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes [J].
Bentley, Stephen D. ;
Aanensen, David M. ;
Mavroidi, Angeliki ;
Saunders, David ;
Rabbinowitsch, Ester ;
Collins, Matthew ;
Donohoe, Kathy ;
Harris, David ;
Murphy, Lee ;
Quail, Michael A. ;
Samuel, Gabby ;
Skovsted, Ian C. ;
Kaltoft, Margit Staum ;
Barrell, Bart ;
Reeves, Peter R. ;
Parkhill, Julian ;
Spratt, Brian G. .
PLOS GENETICS, 2006, 2 (03) :262-269
[7]  
Bergey DH., 1974, Bergey's manual of determinative bacteriology, V8
[8]   Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children [J].
Black, S ;
Shinefield, H ;
Fireman, B ;
Lewis, E ;
Ray, P ;
Hansen, JR ;
Elvin, L ;
Ensor, KM ;
Hackell, J ;
Siber, G ;
Malinoski, F ;
Madore, D ;
Chang, I ;
Kohberger, R ;
Watson, W ;
Austrian, R ;
Edwards, K .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2000, 19 (03) :187-195
[9]   Streptococcus pneumoniae:: Description of the pathogen, disease epidemiology, treatment, and prevention [J].
Bridy-Pappas, AE ;
Margolis, MB ;
Center, KJ ;
Isaacman, DJ .
PHARMACOTHERAPY, 2005, 25 (09) :1193-1212
[10]   The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection [J].
Briles, DE ;
Hollingshead, S ;
Brooks-Walter, A ;
Nabors, GS ;
Ferguson, L ;
Schilling, M ;
Gravenstein, S ;
Braun, P ;
King, J ;
Swift, A .
VACCINE, 2000, 18 (16) :1707-1711