3α-(4-substituted phenyl)nortropane-2β-carboxylic acid methyl esters show selective binding at the norepinephrine transporter

被引：12

作者：

Blough, BE

Holmquist, CR

Abraham, P

Kuhar, MJ

Carroll, FI

机构：

[1] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

[2] Natl Inst Drug Abuse, Addict Res Ctr, Neurosci Branch, Baltimore, MD 21224 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(00)00480-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3 alpha-(4-substituted)nortropane-2 beta -carboxylic acid methyl esters was synthesized and evaluated for the ability to inhibit radioligand binding at the dopamine, serotonin, and norepinephrine transporters. 3 alpha-(4-Methylphenyl)nortropane-2 beta -carboxylic acid methyl ester (4c) was found to be selective and highly potent for the norepinephrine transporter (NET) relative to the dopamine and serotonin transporters. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2445 / 2447

页数：3

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