Transplantation therapy for Parkinson's disease

被引：16

作者：

Borlongan, CV ^{[1
]}

机构：

[1] NIDA, Cellular Neurobiol Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2000年 / 9卷 / 10期

关键词：

clinical trials; immunosuppression; intracerebral grafts; neurodegenerative disorders; Parkinson's disease; trophic factors;

D O I：

10.1517/13543784.9.10.2319

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review paper will provide an overview of the advent of neural transplantation therapy and the milestones achieved over the last 20 years for its use in treating Parkinson's disease. A discussion of technical factors that influence the outcome of neural transplantation is presented, with emphasis given on three sections dealing with immunosuppressants, alternative grafts and trophic factors which have recently been the focus of basic research and development of early phase clinical trials. Some views on the clinical assessment of transplanted Parkinson's disease patients are given at the end of the paper, with a synopsis highlighting the importance of basic research in advancing the potential clinical benefits of neural transplantation therapy in the treatment of Parkinson's disease.

引用

页码：2319 / 2330

页数：12

共 68 条

[1] Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases [J].

Alexi, T ;

Borlongan, CV ;

Faull, RLM ;

Williams, CE ;

Clark, RG ;

Gluckman, PD ;

Hughes, PE .

PROGRESS IN NEUROBIOLOGY, 2000, 60 (05) :409-470

[2] FETAL TISSUE GRAFTING INTO THE CENTRAL-NERVOUS-SYSTEM - YESTERDAY, TODAY, AND TOMORROW [J].

BAKAY, RAE ;

SLADEK, JR .

NEUROSURGERY, 1993, 33 (04) :645-647

[3] Preliminary voice and speech analysis following fetal dopamine transplants in 5 individuals with Parkinson disease [J].

Baker, KK ;

Ramig, LO ;

Johnson, AB ;

Freed, CR .

JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 1997, 40 (03) :615-626

[4] RECONSTRUCTION OF THE NIGROSTRIATAL DOPAMINE PATHWAY BY INTRA-CEREBRAL NIGRAL TRANSPLANTS [J].

BJORKLUND, A ;

STENEVI, U .

BRAIN RESEARCH, 1979, 177 (03) :555-560

[5] Cell replacement therapies for central nervous system disorders [J].

Björklund, A ;

Lindvall, O .

NATURE NEUROSCIENCE, 2000, 3 (06) :537-544

[6] Intracerebral transplantation of testis-derived Sertoli cells promotes functional recovery in female rats with 6-hydroxydopamine-induced hemiparkinsonism [J].

Borlongan, CV ;

Cameron, DF ;

Saporta, S ;

Sanberg, PR .

EXPERIMENTAL NEUROLOGY, 1997, 148 (01) :388-392

[7] Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats [J].

Borlongan, CV ;

Tajima, Y ;

Trojanowski, JQ ;

Lee, VMY ;

Sanberg, PR .

EXPERIMENTAL NEUROLOGY, 1998, 149 (02) :310-321

[8] Intrastriatal transplantation of rat adrenal chromaffin cells seeded on microcarrier beads promote long-term functional recovery in hemiparkinsonian rats [J].

Borlongan, CV ;

Saporta, S ;

Sanberg, PR .

EXPERIMENTAL NEUROLOGY, 1998, 151 (02) :203-214

[9] Cyclosporine A-induced hyperactivity in rats: Is it mediated by immunosuppression, neurotrophism, or both? [J].

Borlongan, CV ;

Stahl, CE ;

Fujisaki, T ;

Sanberg, PR ;

Watanabe, S .

CELL TRANSPLANTATION, 1999, 8 (01) :153-159

[10]

Borlongan CV, 1996, NEUROL RES, V18, P297

← 1 2 3 4 5 6 7 →