Ultrastructural localization of Ani s 1, a major allergen from the fish parasite Anisakis simplex

被引:9
作者
Gómez-Aguado, F
Picazo, A
Caballero, ML
Moneo, I
Asturias, JA
Corcuera, MT
Casado, I
Alonso, MJ
机构
[1] Carlos III Hosp, Dept Pathol, Madrid 28029, Spain
[2] Carlos III Hosp, Dept Immunol, Madrid 28029, Spain
[3] Bial Aristegui Res & Dev Dept, Bilbao, Spain
关键词
Secretory Granule; Enzymatic Function; Secretory Product; Major Allergen; Ultrastructural Localization;
D O I
10.1007/s00436-002-0726-0
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
No data about the nature or function of the first major Anisakis simplex allergen, named Ani s 1, is available. The aim of this study was to investigate the ultrastructural localization of this protein, to obtain further information about it. Ani s I was detected in secretory granules of the excretory gland and occasionally lining the main excretory canal. Our results suggest that Ani s I could be a secretory product and could have an enzymatic function related to mechanisms of infection.
引用
收藏
页码:379 / 380
页数:2
相关论文
共 8 条
  • [1] Ishikura H, 1993, Prog Clin Parasitol, V3, P43
  • [2] Immune response to Anisakis simplex and other ascarid nematodes
    Kennedy, MW
    [J]. ALLERGY, 2000, 55 : 7 - 13
  • [3] ULTRASTRUCTURE OF EXCRETORY SYSTEM OF ANISAKIS LARVA (NEMATODA-ANISAKIDAE)
    LEE, H
    CHEN, I
    LIN, R
    [J]. JOURNAL OF PARASITOLOGY, 1973, 59 (02) : 289 - 298
  • [4] Overview on denominated allergens
    Liebers, V
    Sander, I
    VanKampen, V
    RaulfHeimsoth, M
    Rozynek, P
    Baur, X
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (05) : 494 - 516
  • [5] Isolation and characterization of a major allergen from the fish parasite Anisakis simplex
    Moneo, I
    Caballero, ML
    Gómez, F
    Ortega, E
    Alonso, MJ
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (01) : 177 - 182
  • [6] MORRIS SR, 1994, J BIOL CHEM, V269, P27650
  • [7] A SIMPLE POST-EMBEDDING SYSTEM FOR THE RAPID DEMONSTRATION OF TISSUE ANTIGENS UNDER THE ELECTRON-MICROSCOPE
    NEWMAN, GR
    JASANI, B
    WILLIAMS, ED
    [J]. HISTOCHEMICAL JOURNAL, 1983, 15 (06): : 543 - 555
  • [8] SECRETORY NATURE OF EXCRETORY GLAND CELLS OF STEPHANURUS-DENTATUS .2. PRESENCE OF HYDROLYTIC ENZYMES
    ROMANOWS.RD
    RHOADS, ML
    MALAKATI.GM
    [J]. EXPERIMENTAL PARASITOLOGY, 1973, 34 (01) : 40 - 43