A more detailed fatty acid composition of human lipoprotein(a) - a comparison with low density lipoprotein

Lipoprotein(a)'s (Lp(a)'s) fatty acid composition is partially known for the cholesteryl ester (CE), triglyceride (TG) and total phospholipid (PL) fractions. Individual PLs' fatty acids are unknown. This study sought to confirm and extend existing data and elucidate the individual PLs of Lp(a). For Lp(a) versus LDL, the mole percentage saturated fatty acids comprised 11.3+/-1.3 versus 16.8+/-1.2 (CE) (P < 0.05), 43.4+/-5.2 versus 39.2+/-4.0 (TG) (P < 0.05), 55.7+/-6.3 versus 54.7+/-5.9 (PL) (P > 0.05), 51.9+/-3.5 versus 50.2+/-4.2 (choline-containing phospholipids (PC)) (P > 0.05), 40.2 +/- 4.6 versus 43.1 +/- 3.9 (ethanolamine-containing phospholipids (PE)) (P > 0.05), 73.2+/-7.6 versus 81.2+/-8.2 (sphingo-myelin (SPH)) (P < 0.05). Linoleic acid was CE's major fatty acid and while palmitic acid was the major fatty acid in all other fractions except PE. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.