SETting the stage: Eed-Enx1 leaves an epigenetic signature on the inactive X chromosome

被引：8

作者：

Chadwick, BP ^{[1
]}

Willard, HF

机构：

[1] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27710 USA

[2] Duke Univ, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1534-5807(03)00097-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite evidence implicating the Polycomb group protein, Eed (embryonic ectoderm development protein) in imprinted X inactivation, a similar role in random X inactivation in the embryo has remained an open question. Brockdorff and colleagues now report that Eed, along with its binding partner Enx1, transiently associates with the inactive X chromosome (Xi) and likely contributes to the epigenetic signature and longterm stability of the Xi heterochromatin.

引用

页码：445 / 447

页数：3

共 11 条

[1] Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].

Cao, R ;

Wang, LJ ;

Wang, HB ;

Xia, L ;

Erdjument-Bromage, H ;

Tempst, P ;

Jones, RS ;

Zhang, Y .

SCIENCE, 2002, 298 (5595) :1039-1043

[2] X-chromosome inactivation and the search for chromosome-wide silencers [J].

Cohen, DE ;

Lee, JT .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) :219-224

[3] Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites [J].

Czermin, B ;

Melfi, R ;

McCabe, D ;

Seitz, V ;

Imhof, A ;

Pirrotta, V .

CELL, 2002, 111 (02) :185-196

[4] An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells [J].

Hall, LL ;

Byron, M ;

Sakai, K ;

Carrel, L ;

Willard, HF ;

Lawrence, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) :8677-8682

[5] Re-SET-ting heterochromatin by histone methyltransferases [J].

Jenuwein, T .

TRENDS IN CELL BIOLOGY, 2001, 11 (06) :266-273

[6] Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein [J].

Kuzmichev, A ;

Nishioka, K ;

Erdjument-Bromage, H ;

Tempst, P ;

Reinberg, D .

GENES & DEVELOPMENT, 2002, 16 (22) :2893-2905

[7] Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells [J].

Mak, W ;

Baxter, J ;

Silva, J ;

Newall, AE ;

Otte, AP ;

Brockdorff, N .

CURRENT BIOLOGY, 2002, 12 (12) :1016-1020

[8] Histone methyltransferase activity of a Drosophila polycomb group repressor complex [J].

Müller, J ;

Hart, CM ;

Francis, NJ ;

Vargas, ML ;

Sengupta, A ;

Wild, B ;

Miller, EL ;

O'Connor, MB ;

Kingston, RE ;

Simon, JA .

CELL, 2002, 111 (02) :197-208

[9]

PLATH K, IN PRESS SCIENCE

[10] Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 Polycomb group complexes [J].

Silva, J ;

Mak, W ;

Zvetkova, I ;

Appanah, R ;

Nesterova, TB ;

Webster, Z ;

Peters, AHFM ;

Jenuwein, T ;

Otte, AP ;

Brockdorff, N .

DEVELOPMENTAL CELL, 2003, 4 (04) :481-495

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