学术探索
学术期刊
新闻热点
数据分析
智能评审

The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: concerns over the use of total-body irradiation in systemic sclerosis

被引：18
作者：
Burt, RK
Kallunian, K
Patel, D
Thomas, J
Yeager, A
Traynor, A
Heipe, F
Arnold, R
Marmont, A
Collier, D
Glatstein, E
Snowden, J
机构：
[1] Northwestern Univ, Feinberg Sch Med, Div Immunotherapy, Chicago, IL 60611 USA
[2] Univ Calif San Diego, Div Rheumatol, San Diego, CA 92103 USA
[3] Univ N Carolina, Div Rheumatol, Chapel Hill, NC USA
[4] Vanderbilt Univ, Div Rheumatol, Nashville, TN USA
[5] Univ Pittsburgh, Sch Med, Div Hematol Oncol, Pittsburgh, PA USA
[6] Univ Massachusetts, Div Hematol Oncol, Worcester, MA USA
[7] Free Univ Berlin, Div Rheumatol, Charite Hosp, D-1000 Berlin, Germany
[8] Free Univ Berlin, Div Bone Marrow Transplantat, Charite Hosp, D-1000 Berlin, Germany
[9] Univ Colorado, Div Rheumatol, Denver, CO 80202 USA
[10] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[11] Sheffield Teaching Hosp NHS Trust, Sheffield, S Yorkshire, England
[12] Univ Sheffield, Blood & Marrow Transplant Programme, Sheffield, S Yorkshire, England
来源：
BONE MARROW TRANSPLANTATION | 2004年 / 34卷 / 09期
关键词：
D O I：
10.1038/sj.bmt.1704671
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Hematopoietic stem cell transplantation (HSCT) is becoming an increasingly recognized indication for treatment of autoimmune diseases and severe immune-mediated disorders. However, multicenter registry data have demonstrated higher than anticipated early toxicity, approximately 10% for autoimmune diseases in general, and 20-27% for diffuse systemic sclerosis (scleroderma). If uncorrected, this high treatment-related mortality will hinder development of stem cell therapy for immune-mediated diseases. In order to develop safer regimens, we address some pitfalls and concepts involved in design and selection of conditioning regimens for autoimmune diseases in general, and because it is associated with the highest regimen-related toxicity, scleroderma in specific.
引用
收藏
页码：745 / 751
页数：7
相关论文
共 74 条
[1]  
ABUSHAKRA M, 1993, J RHEUMATOL, V20, P1601
[2]   PLANT DNA TOPOISOMERASE-I IS RECOGNIZED AND INHIBITED BY HUMAN SCL-70 SERA AUTOANTIBODIES [J].
AGRIS, PF ;
PARKS, R ;
BOWMAN, L ;
GUENTHER, RH ;
KOVACS, SA ;
PELSUE, S .
EXPERIMENTAL CELL RESEARCH, 1990, 189 (02) :276-279
[3]   Severe fibrosis in a patient with scleroderma and previous radiotherapy - A case report and literature review [J].
Aref, I ;
Cross, P ;
Nair, B .
BRITISH JOURNAL OF RADIOLOGY, 1996, 69 (827) :1055-1056
[4]   EARLY EFFECTS OF RADIATION ON RENAL FUNCTION IN MAN [J].
AVIOLI, LV ;
COTLOVE, E ;
BRACE, KC ;
LAZOR, MZ ;
ANDREWS, JR .
AMERICAN JOURNAL OF MEDICINE, 1963, 34 (03) :329-&
[5]   TOTAL LYMPHOID IRRADIATION IN REFRACTORY SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
BENCHETRIT, E ;
GROSS, DJ ;
BRAVERMAN, A ;
WESHLER, Z ;
FUKS, Z ;
SLAVIN, S ;
ELIAKIM, M .
ANNALS OF INTERNAL MEDICINE, 1986, 105 (01) :58-60
[6]   Phase I/II trial of autologous stem cell transplantation in systemic sclerosis:: procedure related mortality and impact on skin disease [J].
Binks, M ;
Passweg, JR ;
Furst, D ;
McSweeney, P ;
Sullivan, K ;
Besenthal, C ;
Finke, J ;
Peter, HH ;
van Laar, J ;
Breedveld, FC ;
Fibbe, VE ;
Farge, D ;
Gluckman, E ;
Locatelli, F ;
Martini, A ;
van den Hoogen, F ;
van de Putte, L ;
Schattenberg, AVN ;
Arnold, R ;
Bacon, PA ;
Emery, P ;
Espigado, I ;
Hertenstein, B ;
Hiepe, F ;
Kashyap, A ;
Kötter, I ;
Marmont, A ;
Martinez, A ;
Pascual, MJ ;
Gratwohl, A ;
Prentice, HG ;
Black, C ;
Tyndall, A .
ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (06) :577-584
[7]   DEMONSTRATION OF EFFECT OF IRRADIATION ON CANINE BOWEL USING IN-VIVO PHOTOGRAPHIC MAGNIFICATION ANGIOGRAPHY [J].
BOSNIAK, MA ;
HARDY, MA ;
QUINT, J ;
GHOSSEIN, NA .
RADIOLOGY, 1969, 93 (06) :1361-&
[8]   MORTALITY FROM CANCER AND OTHER CAUSES AFTER RADIOTHERAPY FOR ANKYLOSING SPONDYLITIS [J].
BROWN, WMC ;
DOLL, R .
BRITISH MEDICAL JOURNAL, 1965, 2 (5474) :1327-&
[9]   Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring? [J].
Burt, RK ;
Oyama, Y ;
Traynor, A ;
Quigley, K ;
Brush, M ;
Rodriguez, J ;
Barr, WG .
BONE MARROW TRANSPLANTATION, 2003, 32 (Suppl 1) :S65-S67
[10]   Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores [J].
Burt, RK ;
Cohen, BA ;
Russell, E ;
Spero, K ;
Joshi, A ;
Oyama, Y ;
Karpus, WJ ;
Luo, KH ;
Jovanovic, B ;
Traynor, A ;
Karlin, K ;
Stefoski, D ;
Burns, WH .
BLOOD, 2003, 102 (07) :2373-2378
12345678